By : Lamiaa Moustafa Elbosaty
Dementia due to Creutzfeldt-Jakob Disease: It is a rare, rapidly progressive neurodegenerative disorder that results in dementia and sever neurological impairment. It is the main prion disease with an approximate annual incidence of one case per million. The age of onset is 65 to 79, with a sharp decline in incidence over age 79. The duration of the disease is 2 to 9 months, however, some cases have lasted 2 to 5 years (Will et al., 2004). The human form of this prion disease is variant Creutzfeldt-Jakob disease, which is due to the transmission of bovine prions to humans through the consumption of cattle infected with bovine spongiform encephalopathy "mad cow disease" (Bacchetti, 2003).
According to Neary and Snowden (2003), the clinical characteristics of Creutzfeldt-Jakob disease are rapidly progressive dementia, behavior disturbance, and motor disturbance including myoclonic prodromal symptoms which may include fatigue, sleep disturbance, memory disturbance, mild behavioral changes, depression, vertigo, and seizures
occur later in the course. There is usually a rapid progression to death often with 6 months.
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